给药间隔干预对门诊抗菌药物注射剂安全性的影响.PDF

给药间隔干预对门诊抗菌药物注射剂安全性的影响 朱立勤，徐彦贵，冯艳霜，陈凡，王屏，高仲阳(天津市第一中心医院，天津 300192) 摘要：目的 针对给药间隔因素分别对临床进行干预，观察药品不良反应发生率的变化，旨在提高门诊抗菌药物注射剂的 用药安全性。方法 采用前瞻性随机对照方法，选取天津市第一中心医院 2007 年 1 月—2007 年 12 月的门诊中使用抗菌药 物注射剂的患者为研究对象，随机分为对照组和干预组，采用培训教育、资料整理和发放、行政监督等干预措施，针对给 药间隔因素进行干预并分析。结果 与对照组相比，干预组给药间隔明显更加合理(P ＜0.01) ，干预后不良反应的发生率明 显降低(P ＜0.01)。结论 对给药间隔的干预效果明显，不良反应发生率大大降低，对该因素干预有效。 关键词：抗菌药物注射剂；安全性；干预；给药间隔 中图分类号：R969.3 文献标志码：B 文章编号：1007-7693(2010)04-0374-03 The Effect of Administration Intervals Intervention on the Safty of Antimicrobial Injections in Outpatients ZHU Liqin, XU Yangui, FENG Yanshuang, CHEN Fan, WANG Ping, GAO Zhongyang(The First Central Hospital of Tianjin, Tianjin 300192, China) ABSTRACT: OBJECTIVE Considering the administration intervals to intervene the clinics, the incidence of adverse drug reactions was observed to improve the medication safety of antibiotics injection in outpatients. METHODS With a prospective randomized controlled method, the outpatients using antimicrobial agents, selected from the first central hospital of Tianjin in January—December 2007, were randomly divided into control group and intervention group. The intervention measures of training and education, information collation and dissemination, and administrative supervision were used and analyzed. RESULTS Compared with the control group, the intervention group significantly had more rational administration interval (P0.01), the incidence of adverse reactions after the intervention was significantly lower(P0.01). CONCLUSION The intervention effect on the administration interval significantly reduced the incidence of adverse reactions. The intervention was effective. KEY WORDS : antimicrobial injections; safety; intervene; the administration interval 作者简介：朱立勤，女，硕士，主任药师，硕导 Tel: (022 E-mail: zlq0713@ ·374