A review on solid dispersion Sakun Publications（综述固体分散Sakun出版物）.pdf

Review Article [Singh et al., 2(9): Sep., 2011] ISSN: 0976-7126 INTERNATIONAL JOURNAL OF PHARMACY LIFE SCIENCES A review on solid dispersion 1 2 3 Sameer Singh *, Raviraj Singh Baghel and Lalit Yadav 1, Institute of Pharmacy Vikram University Ujjain, (M.P) - India 2, School of Pharmacy, Bhopal, (M.P) - India 3, Rajeev Gandhi College of Pharmacy, Bhopal, (M.P) - India Abstract Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The focus of this review article on advantages, disadvantages and the method of preparation, and characterization of the solid dispersion. Key-Words: Solubility, Solid Dispersions, Carrier, Bioavailability Introduction The resulting enhanced surface area produces higher The enhancements of oral bioavailability of such dissolution rate and bioavailability of poorly water- poorly water-soluble drugs often show poor soluble drugs. In addition, in solid dispersions, a bioavailability because of low and erratic levels of portion of drug dissolves immediately to satura