AGGRESSIVE TREATMENT IN NEWLY （积极的治疗在新）.pdf

AGGRESSIVE TREATMENT IN NEWLY DIAGNOSED DIABETES WITH FIXED DOSE COMBINATIONS 5 : 4 Sanjay Kalra, Karnal INTRODUCTION The importance of early and optimal control of glycemia in diabetes is well known. The need for multiple drugs, focusing on the various pathophysiologic mechanisms that cause diabetes, is also well understood. The less-than-acceptable results of our therapy, too, are no secret. Our inability to achieve desired glycemic goals is due, in part, to poor compliance, adherence and persistence with / to suggested antidiabetic therapy. One way in which we can improve adherence and persistence to therapy, is by using appropriate fixed dose combination (FDC) preparations. Early and proactive use of appropriate FDCs is a simple and effective way of achieving glycemic and other targets. This chapter discusses the utility of FDCs in the management of diabetes. THE DIABETES BURDEN The oft-quoted statistics of the diabetes pandemic1 are unable to quantify the burden of disease that individuals with diabetes have to face. A diagnosis of diabetes brings with it a financial, professional, social and personal load that has to be shouldered life- long. The physical, mental, time-related and economic stress of taking various tablets and injections, self monitoring of glucose, related investigations, and medical consultations are difficult to estimate.