丁苯酞注射液治疗急性脑梗死疗效的初步探讨 - 中华老年多器官疾病杂志.doc

·临床研究· 丁苯酞注射液治疗急性脑梗死疗效的初步探讨 唐 鹏，刘 玥，刘 鹏，种 莉，李晓青，陈 丽，郭民侠，李 锐* （陕西省人民医院神经内三科，西安 710068） 【摘 要】目的 评价丁苯酞注射液对急性脑梗死的疗效及药物不良反应。方法 选择陕西省人民医院70例急性脑梗死住院患者随机分为治疗组（n＝＝P＝P＝P＝R743.33 【文献标识码】 A 【DOI】 ? Dl-3-n-butyphthalide for the treatment of acute cerebral infarction TANG Peng, LIU Yue, LIU Peng, CHONG Li, LI Xiao-Qing, CHEN Li, GUO Min-Xia, LI Rui* (The Third Department of Neurology, Shaanxi Provincial Peoples Hospital, Xi’an 710068, China) 【Abstract】 Objective To evaluate the therapeutic effects and adverse drug reactions of Dl-3-n-butyphthalide (NBP) injection for acute cerebral infarction. Methods Seventy cases of acute cerebral infarction patients from Shaanxi Provincial Peoples Hospital were randomly divided into standard treatment plus Dl-3-n-butyphthalide injection (n＝35) and standard treatment (Control, ＝35). The degree of neurological deficit (NIHSS score) and daily living skills assessment (Barthel Index and the mRS score) were assessed and adverse reactions were recorded before and 14 days after the treatment. Barthel Index and the mRS score were followed up 90 days after the treatment. Results After 14 days, NIHSS scores of both NBP and control groups were decreased as compared with pretreatment. The decrease of NIHSS in NBP group was more significant than control group [NBP group (13.60?4.26) vs (9.31?3.79), control group (13.57?4.20) vs (11.23?4.06), P＝0.045)]. No obvious change in Barthel index in two groups were identified at 14 days after treatment.Barthel index at 90 days of follow-up were significantly higher in NBP group than control group [NBP group (54.57±24.17) vs (77.86±21.46), control group (54.14±23.81) vs (67.0±23.30), P＝0.047]. After 14 days, mRS scores of both groups did not change significantly; after 90 days, the decrease of mRS scores in NBP group was more significant than control group [NBP group (3.400.81) vs (2.80±0.96), control group (3.49±0.82) vs (3.29±0.93), P＝0.035]. Incidence of adverse reactions was similar betw