关于有机合成的论文.docVIP

关于有机合成的毕业论文 目 录 第一章 前言 2 1.1 3，3＇，5，5＇-四甲基联苯胺的概述 2 1.2 国内外有关3，3＇，5，5＇-四甲基联苯胺的研究进展 4 1.3 选题意义 5 第二章 实验部分 6 2.1仪器和试剂 6 2.1.1实验仪器 6 2.1.2实验试剂 6 2.2 3，3＇，5，5＇-四甲基联苯胺的合成与研究 7 2.2.1合成原理 7 2.2.2合成方法 7 第三章 结果与讨论 10 3.1 溴化反应 10 3.2 偶联反应 10 3.2.1 反应温度对偶联反应的影响 11 3.2.2 原料配比对偶联反应的影响 12 3.3 溴化产物的表征图谱 12 第四章 结论 13 参考文献 14 致 谢 15 3,3,5,5-四甲基联苯胺的合成研究 制药工程专业 **级 *** 摘要关键词：The Synthesis of 3,3,5,5-Tetramethylbenzidine HuangLiyan,Grade 2009,Pharmarcettical Engineering Abstract: 3,3,5,5- tetramethylbenzidine is a new kind of safe color reagent. With traditional chromogen reagents such as benzidine, adjacent tolidine and compared o-phenylendiamine etc, has the advantages of high detection sensitivity, good stability, and the use of safe, no carcinogenic and mutagenic effects. Currently 3,3,5,5- tetramethyl benzidine has been gradually replaced by strong carcinogens benzidine and other carcinogenic benzidine derivatives, the application in the clinical laboratory, field of forensic examination, forensic and environmental monitoring. Especially in the aspects of clinical and biochemical examination, 3,3,5,5- tetramethyl benzidine as new substrates of peroxidase, the enzyme immunoassay (EIA) and enzyme-linked immunosorbent test (ELISA) has gained wide application. 3,3,5,5-Tetramethylbenzidine was synthesized by using 2 , 6-dimethyl aniline as the starting material via salting, bromination, hydrolysis and coupling. The total yield of four steps was 46. 56%. Structure of the product was confirmed by 1HNMR. This method has many advantages, such as easy operation and low cost, which can be feasible to large scale preparation. Key words: 2 , 6-dimethyl aniline; bromination; coupling; 3,3,5,5-Tetramethyl- benzidine 第一章 前言 1.1 3,3,5,5-四甲基联苯胺的概述 联苯胺类化合物具体可分两大类，一类是:双联苯的苯环上2,2、3,3、5,5和6,6位被－H、－R、－OR、－NH2、－SO3H 和－Cl等基团取代的化合物( 其中R为甲基、丙基及丁基) ，如联苯胺、3,3-二甲氧基联苯胺、3,3－二甲基联苯胺、3,3－二氨基联苯胺、2,2－二磺酸基联苯胺、3,3,5,5-四甲基联苯胺、3,3－二氯联苯胺、3,3,5,5－四氯联苯胺、3,3－二丙氧基联苯胺和3,3－二丁氧基联苯胺等; 另一类是: 4,4位氨基N上的H被－R、－CH3CO、－C6H5和