Botulinum toxin type A in Prostate Disease Research课件.ppt

Botulinum toxin type A in Prostate Disease Research;Background;As early as 1960, U.S. scientists have succeeded in botulinum toxin type A was prepared and used for the treatment of muscle tension diseases.;What is botulinum toxin type A(BTX-A)?;Mechanism;Add Your Title;Aoki KR : BTX-A inhibits the feelings of peripheral sensitivity to pain stimulation Aoki KR. Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A. Neurotoxicology, 2005, 26(5): 785-793.;BTX-A in Prostate Disease ; Maria G: 30 patients with voiding dysfunction B ultrasound-guided in the rectum, the BTX-A injection in the prostate tissue Symptom score, PSA, prostate volume, residual urine volume decreased urinary flow rate increased Discussion 264-5.Relief by botulinum toxin of voiding dysfunction due to benign prostatic hyperplasia: results of a randomized, placebo-controlled study,Urology. 2003 Aug;62(2):259-64; ;Nikoobakht M: PSA and PV substantially decreased after 6 months (p 0.001). No serious complications were reported. It seems that the toxin efficacy depends directly on PV in prostates 60 ml. Nikoobakht M, Daneshpajooh A, Ahmadi H, et al. Intraprostatic botulinum toxin type A injection for the treatment of benign prostatic hyperplasia: Initial experience with Dysport. Scand J Urol Nephrol. 2010 Apr;44(3):151-7.;Significantly reduce the accumulation of inflammatory cells and COX2 expression so that pain relief, inflammation subsided Chuang YC, Yoshimura N, Wu M, Huang CC,Intraprostatic capsaicin injection as a novel model for nonbacterial prostatitis and effects of botulinum toxin A. Eur Urol. 2007 Apr;51(4):1119-27. Epub 2006 Nov 27.;;Urge urinary incontinence after prostatectomy ;transurethral injection ;Botulinum toxin is now known to one of the most toxic biological toxin. The human lethal dose is 0.1-1ug, the usual dose of prostaglandin injection 100-300U. There were no products in domestic and foreign reports of systemic toxicity, onl