乳腺癌新辅助化疗疗效生物学预测指标的研究进展.PDFVIP

中国普外基础与临床杂志 2017 年x 月第24 卷第x 期 • 1 •   ·综 述· 乳腺癌新辅助化疗疗效生物学预测指标的 研究进展 谭龙涛，滕晓飞，程凯，王晓红，刘健，张英哲，杨振林 滨州医学院附属医院甲状腺乳腺外科（山东滨州  256600 ） 【摘要】   目的    总结乳腺癌新辅助化疗疗效生物学预测指标的研究进展。方法     阅读近年来相关文献，对 乳腺癌行新辅助化疗后疗效的生物学预测指标进展加以综述。结果    既往研究显示，许多生物学指标可能与乳 腺癌新辅助化疗疗效相关，如人表皮生长因子受体-2 （HER-2 ）基因、雌激素受体（ER ）、孕激素受体（PR ）、Ki-67、 P53 基因、中性粒细胞和淋巴细胞的比值（NLR ）、血小板水平、血小板平均体积（MPV ）等，但具体预测价值尚未 达成一致结论。结论    各种因子对乳腺癌新辅助化疗疗效的预测价值尚不确定，需待进一步研究。 【关键词】  乳腺癌；新辅助化疗；生物学标志物；病理完全缓解；综述 Research progress on biological indexes which predict the efficiency of neoadjuvant chemotherapy for breast cancer TAN Longtao, TENG Xiaofei, CHENG Kai, WANG Xiaohong, LIU Jian, ZHANG Yingzhe, YANG Zhenlin Thyroid and Breast Surgery, Binzhou Medical University Hospital, Binzhou, Shandong 256600, P.R.China Corresponding author: YANG Zhenlin, Email: Yangzhenlin918@163.com 【Abstract 】 Objective    To summarize the progress of biological indexes which could predict the efficiency of neoadjuvant chemotherapy for breast cancer. Method    Various related researches were collected to make a review. Results    Many indexes link to the efficiency of neoadjuvant chemotherapy for breast cancer according to several studies. According to many studies, indexes such as human epidermal growth factor receptor-2 (HER-2) gene, estrogen receptor (ER), progesterone receptor (PR), Ki-67, P53 gene, neutrophil to lymphocyte ratio (NLR), platelet level, and mean platelet volume (MPV) may had association with the outcome of neoadjuvant chemotherapy in treatment of breast cancer, and these factors maybe individual biomarkers to predict the efficiency of the treatment, but no coincident conclusion had been reached for these indexes. Conclusions    The value of