酸性鞘磷脂酶对肿瘤生长的影响及其应用价值-tumor.PDFVIP

564 　　肿瘤2012 年7 月第32 卷第7 期　TUM OR Vol. 32, J uly 2012 DOI: 10.3781/j .issn.1000-7431.2012 .07.016 Copyright© 2012 by TUM OR Review 综述 · 酸性鞘磷脂酶对肿瘤生长的影响及其应用价值 张百红，岳红云 兰州军区兰州总医院肿瘤科，兰州　730050 [ 摘要 ]　酸性鞘磷脂酶 （acid sphingomyelinase ，aSMase ）是鞘酯类代谢中一种重要的酶。关于 aSMase 在肿瘤中 作用的研究还较少，但已发表的研究提示其与肿瘤的发生和发展有一定的关系。本文对 aSMase 的激活机制、在肿 瘤生长中的作用及其应用价值进行了综述。 [ 关键词 ]　肿瘤；酸性鞘磷脂酶；肿瘤发生 [中图分类号]　R730.2 [文献标志码] A [文章编号]　1000-7431 (2012) 07-0564-03 The role of acid sphingomyelinase in the development and progression of tumors and its application value ZHANG Bai-hong, YUE Hong-yun Department of Oncology, Lanzhou General Hospital, Lanzhou Military Area Command of China Pepole’s Liberation Army, Lanzhou 730050, China [ABSTRACT]　Acid sphingomyelinase (aSMase) is an important enzyme in sphingolipid metabolism. Studies concerning the relationship between aSMase and tumor are relatively rare. However, the relationship between aSMase and the development and progression of tumors has already been demonstrated in previously published research. In this review, the mechanism of aSMase activation and the role of aSMase in the development and progression of tumors as well as its application value are summarized. [KEY WORDS]　 Neoplasms; Acid sphingomyelinase; Tumorigenesis TUMOR , 2012, 32 (07): 564-566] [ 酸性鞘磷脂酶 （acid sphingomyelinase，aSMase ）是鞘 1　aSMase 信号通路 脂类代谢中一种重要的酶，在细胞凋亡、免疫、发育和肿 3 瘤生长中发挥关键作用[1] 。aSMase 主要分布于溶酶体，可 aSMase 编码基因位于11P15.1 ～ 15.4，长约5×10 bp，