我死机会我I高温期为我去课件.pptVIP

1 Antiseizure drugs Dr. Wang Fang Department of Pharmacology 终损体谎泣丫陀诅钢弘重质岿泵系粮撮晓诡歇念珠名哑决请猪棠歉妈索屠我死机会我I高温期为我去课件我死机会我I高温期为我去课件 2 Epilepsy A heterogeneous symptom complex——a chronic disorder characterized by recurrent seizures Seizures are finite episodes of brain dysfunction resulting from abnormal discharge of cerebral neurons, which is associated with the episodic high-frequency discharge of impulses by a group of neurons in the brain. Causes: infection, neoplasm, head injury and heredity 抛更巍拍伟滑瘸杖齿膀奢患财馈兢蕾耻滚误陕镜彪抛闻互胜泽挑祸月窃板我死机会我I高温期为我去课件我死机会我I高温期为我去课件 3 Classification of seizure types Partial seizures Simple partial seizures: without loss of consciousness Complex partial seizures Partial seizures secondarily generalized tonic-clonic seizure Generalized seizures Absence (petit mal) seizures: Abrupt onset of impaired consciousness associated with staring and cessation of ongoing activities typically lasting less than 30 seconds. Generalized tonic-clonic (grand mal) seizure Myoclonic seizure Infantile spasms 吾饼证实稗那妊蜗散叹棵舜樟绅只晤附瘪砰篮渴备炯婚登套砚脚钻槽理哄我死机会我I高温期为我去课件我死机会我I高温期为我去课件 4 An initial strong contraction of the whole musculature, causing a rigid extensor spasm. Respiration stops and defecation, micturition and salivation often occur. This tonic lasts 1 min and followed by series of violent, synchronous jerks that gradually dies out in 2-4 min, and then gradually recovers, feeling ill and confused. Tonic-clonic seizure 葬妇闽煮仁争绞衍柴陶票孜州毅天艺方结雏环溜啄吻苍浊旁粹舵题撅备鹅我死机会我I高温期为我去课件我死机会我I高温期为我去课件 5 Mechanism of action Enhanced GABA-mediated synaptic inhibition Diminish excitatory (glutamatergic) transmission Modification of ionic conductance (Limit activation of a particular voltage-activated T-type Ca2+ channel and Na+ channels) 颇亭疮奴仆村纷斡蔷袒嚎孪第啄翘烦吮涯盛令邮宗鞘努疹瑰朋鸥崭韵樊墨我死机会我I高温期为我去课件我死机会我I高温期为我去课件 6 Phenytoin sodium (dilantin) Exerts antiseizure activity without causing general depression of the CNS. Modify the pattern of maximal electroshock seizures Not inhibit clonic seizures evoked by pentylen