酪酸梭菌对不同年龄段腹泻患儿治疗效果影响.docVIP

酪酸梭菌对不同年龄段腹泻患儿治疗效果影响【摘要】　目的：探讨年龄因素是否能影响酪酸梭菌对小儿腹泻病的治疗效果。方法：将第1组(G1组)的96例年龄在0～11个月的急性腹泻患儿随机分为对照1组(C1组)和治疗1组(T1组)各48例；将第2组(G2组)的112例年龄在12～59个月的急性腹泻患儿随机分为对照2组(C2组)和治疗2组(T2组)各56例，C1组与C2组患儿给予常规治疗，T1组患儿在常规治疗基础上加用口服宝乐安(主要成分为酪酸梭菌)500 mg， 2次/d；T2组患儿在常规治疗基础上加用口服宝乐安500 mg，3次/d；比较治疗后各组患儿的临床疗效。结果：T1组患儿较C1组患儿治疗效果显著，T2组患儿较C2组患儿治疗效果显著，差异均有统计学意义(P0.05)；且G1组较G2组治疗效果更明显(P0.05)。结论：酪酸梭菌可用于治疗小儿急性腹泻，且治疗效果受年龄因素的影响。 【关键词】　年龄因素；　酪酸梭菌；　腹泻；　儿童 Age Affect the Response to Clostridium Butyricum Therapy for Diarrhoea in Children/XU Ai-ping，SUN He-sheng，XIA Jiang-hong，et al.//Medical Innovation of China，2012，9(25):012-013 【Abstract】　Objective:To explore weather the age factor can affect the response to Clostridium butyricum therapy for diarrhoea in children. Method:96 children aged less than eleven months were randomly divided into control 1 group (C1) and the treatment 1 group (T1).112 children aged six months to five years were randomly divided into control 2 group (C2) and the treatment 2 group (T2).T1 and T2 groups recommended Clostridium butyricum for the management of diarrhoea，in addition to basic treatment.Observed the efficacy of Clostridium butyricum for the treatment of diarrhoea on the duration of diarrhoea.Result:The trends suggested that there may be a benefit of Clostridium butyricum for the treatment of diarrhoea on the duration of diarrhoe，and the G1 group was better than the G2 Group(P0.05).Conclusion:Treatment with clostridium butyricum significantly reduces the duration of diarrhoea and the effect is age-dependent. 【Key words】　Age factor;　Clostridium butyricum;　Diarrhoea;　Child First-author’s address:Changyi People’s Hospital of Shandong Province，Changyi 261300，China doi：10.3969/j.issn.1674-4985.2012.25.006 小儿腹泻病是一组由多病原、多因素引起的以大便次数增多和大便性状改变为特点的消化道综合征，在我国5岁以下儿童每年有2.98亿人次患腹泻，年发病率平均为2.5次/人[1]，是第三世界国家小儿第一位常见多发病与死因[2]。酪酸梭状芽孢杆菌(Clostridium butyricum)是属于硬壁菌门梭菌属的一种革兰阳性菌，严格的厌氧菌(简称酪酸梭菌)，是一种正常肠道菌群[3]，在调节肠道的微生态平衡，预防和治疗腹泻、肠炎等疾病中的作用已被人们广泛认识，但目前国内外尚无报道显示酪酸梭菌对腹泻病的婴儿及幼儿治疗效果存在差异。为此