豚鼠原发性骨关节炎的生化研究.PDFVIP

# 212 # 2001 4 14 4 China J Orthop T rauma, April 2001, Vol. 14, No. 4 1 1 1 2 蓝旭 刘雪梅 葛宝丰 许建中 ( 1 , 730050; 2 , ) , , Hartley 30 , 137 , 10 , , 3 , ( P 001) Observation on Biochemical Features of Primary Osteoarthritis of Guinea PigsLA N X u , L I U X uemei, GE Baof eng , et al . General H osp ital of L anz hou M ilitary a Gansu L anz hou, 730050) Abstract Objective To investigate the biochemical changes of primary osteoarthritis of the nee joint of guinea pigs and study its initial pathogenesis. Methods 30 female Hartley guinea pigs were divided in to postnatal 1, 3 and 7 months groups w ith 10 animals in each group.T he degeneration of nee joint cartilage w as observed. The proteoglycan( PG) and estradiol( ET) in serum w ere measured and the contents of hydrox yproline( HOP) , uronic acid( UA) and water ratio( WR) in articular cartilage were determined. Results Re mar able degeneration of nee joint cartilage was seen in guinea pigs of 3 months old.T he level of serum ET and cartilage WR increased with age,w hile the value of serum PG and cartilage UA decreased w ith age. The conent of HOP had no significant difference among 3 groups. Conclusion Biochemical features of primary os teoarthritis in serum and cartilage changed significantly w ith age. Estradiol metabolism may attribute to the pathogenesis of primary osteoarthritis. Key Words Osteochondritis Knee joint Cartilage ( OA) , , , [ 1, 2] , Hartley , , OA , OA , [ 3] 3 , , , Reddy [ 5] [ 6] , , Suzu i , OA ( 3) !