西交《生物药剂与药动学》在线作业（Online operation of biological medicine and pharmacokinetics）.docVIP

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西交《生物药剂与药动学》在线作业（Online operation of biological medicine and pharmacokinetics）.doc

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西交《生物药剂与药动学》在线作业（Online operation of biological medicine and pharmacokinetics）

西交《生物药剂与药动学》在线作业（Online operation of biological medicine and pharmacokinetics） Online operation of biological medicine and pharmacokinetics Total score: 100 test time: - Radio examination A multiple-choice question Judgment question Radio examination questions (30 questions, 60 points) 1., the t1/2 of a drug is 1 hours, and 40% of the prototype drugs are excreted by the kidney, and the rest are biologically transformed. The rate of biotransformation is about Kb A. 0.05 hours -1 B. 0.78 hours -1 C. 0.14 hours -1 D. 0.99 hours -1 E. 0.42 hours -1 Full marks: 2 2., it is not the mechanism of gastrointestinal absorption of drugs A. promotes diffusion B. permeation C. endocytosis D. passive diffusion Full marks: 2 3. in the following statement about the apparent volume of distribution of the drug, what is correct is that The apparent volume of A. is large, indicating a small concentration of the drug in the plasma B. apparent volume of distribution indicates the actual volume of the drug in the body C. apparent volume cannot exceed body fluid volume D. the apparent volume of the unit is rise / hour The distribution volume of E. is of physiological significance Full marks: 2 4. after several doses or repeated administration, after several half lives, the drug concentration in the body reaches steady state A. 3 B. 10 C. 4-5 D. 6-7 Full marks: 2 5. the constant rate of elimination of lidocaine was 0.3465h, and its biological half-life was determined A. 4H B. 1.5h C. 2.0h D. O.693h E. 1H Full marks: 2 6. it is known that a drug takes a great effect on the liver after oral administration, and then uses muscle injection A. t1/2 was unchanged and bioavailability increased B. t1/2 was unchanged and bioavailability decreased C. t1/2 increased and bioavailability increased D. t1/2 decreased and bioavailability decreased E., t1/2, and bioavailability did not change Full marks: 2 7. the significance of alpha in the multi compartment model is... A. elimination rate constant B. absorp