42 抗结核病药及抗麻风病药（42 anti tuberculosis drugs and anti leprosy drugs）.docVIP

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42 抗结核病药及抗麻风病药（42 anti tuberculosis drugs and anti leprosy drugs）.doc

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42 抗结核病药及抗麻风病药（42 anti tuberculosis drugs and anti leprosy drugs）

42 抗结核病药及抗麻风病药（42 anti tuberculosis drugs and anti leprosy drugs） The forty-fourth chapter of anti TB drugs and anti leprosy drug There are many kinds of anti TB drugs, the clinical efficacy, less adverse reaction, low cost and convenient use of the drug known as first-line anti tuberculosis drugs, according to the domestic situation, to isoniazid, streptomycin and para aminosalicylic acid sodium as first-line anti tuberculosis drugs, many countries have B ETHAMBUTOLE replaced streptomycin and convenient to aminosalicylic acid sodium in the first-line anti tuberculosis drugs. 44.1 isoniazid (isoniazid, rimifon, INH) Nature is stable, soluble in water, has the advantages of high efficiency, low toxicity, low cost and convenient application etc.. pharmacological action Have highly selective effect on Mycobacterium tuberculosis of other bacteria, no effect, strong antibacterial activity, has bactericidal effects on growth and reproduction in the period of Mycobacterium tuberculosis, and to improve the concentration of stationary phase bacteria killing effect. Good penetrability, which can penetrate into macrophages, can penetrate the fibers and hollow stem like lesions, 500 times stronger than the activity of streptomycin. Isoniazid single resistance bacteria, such as a separate application for 3 months, about 70% cases of sputum isolated drug-resistant strains, such as streptomycin, rifampicin and containing, can greatly retard drug resistance and enhance the curative effect. The antibacterial mechanism has not been fully elucidated, may interfere with bacterial protein, folic acid, sugar and fat metabolism, and inhibits mycolic acid synthesis, and the death of bacteria. In the process of Oral absorption of fast and complete, after 1 to 2 hours to reach the peak of blood drug concentration, is widely distributed in various tissues and body fluids, meningeal inflammation, concentration in cerebrospinal fluid with the same blood concentration almost equal, can also pene