牛蒡子苷大鼠在体肠吸收动力学研究-天津中草药杂志社.PDFVIP

中草药 Chinese Traditional and Herbal Drugs 第 44 卷 第 6 期 2013 年 3 月 ·727 · 牛蒡子苷大鼠在体肠吸收动力学研究 李沉纹，罗明和，李卓恒，于彩平，管海燕，卢来春* 第三军医大学大坪医院野战外科研究所 药剂科，重庆 400042 摘 要：目的 研究牛蒡子苷在大鼠小肠内的吸收动力学特征。方法 采用大鼠在体肠灌流方法建立牛蒡子苷大鼠肠吸收模 型，考察牛蒡子苷在大鼠小肠的吸收情况，计算牛蒡子苷的吸收速率常数（Ka ）、吸收半衰期（t1/2 ）、单位时间吸收率（P ）、 表观渗透系数（P ）。结果 牛蒡子苷 10～50 μg/mL 在肠道吸收的 K 、t 、P 、P 值不随质量浓度的变化而变化，基本 app a 1/2 app 保持恒定。结论 牛蒡子苷在大鼠体内的小肠吸收符合一级动力学过程，吸收机制为被动转运。 关键词：牛蒡子苷；肠吸收；动力学特性；在体肠灌流；被动转运 中图分类号：R969.1 文献标志码：A 文章编号：0253 - 2670(2013)06 - 0727 - 04 DOI: 10.7501/j.issn.0253-2670.2013.06.018 In vivo absorptive dynamics of arctiin in intestine of rats LI Chen-wen, LUO Ming-he, LI Zhuo-heng, YU Cai-ping, GUAN Hai-yan, LU Lai-chun Department of Pharmacy, Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, Chongqing 400042, China Abstract: Objective To investigate the in vivo absorptive characteristic of arctiin in small intestine of rats. Methods The intestine absorption model of arctiin was established by in vivo intestinal perfusion method. The absorption rate constants (Ka), absorption half time (t1/2), absorption percent of per unit of time (P), and apparent permeability coefficient (Papp) were calculated and compared to investigate the absorptive dynamics of arctiin in intestine of rats. Results At the concentration range of 10—50 μg/mL, Ka, t1/2, P, and Papp showed no significant difference, and had no connection with concentration of arctiin. Conclusion Arctiin complies with the first-order absorptive kinetics and the absorptive mechanism in intestine may be passive transport. Key words: arctiin; absorption in intestine; dymamic characteristic; in vivo intestinal perfusion; passive transport 牛蒡子苷（arctiin ）是牛蒡子中的有效成分， 都市科龙化工试剂厂；甲