^18F—FDG PET显像在复发性卵巢癌诊断中的应用.pdfVIP

张振宇等 F—FDG PET显像在复发性卵巢癌诊断中的应用 第5期 · 687· · 实验与基础研究· F—FDG PET显像在复发性卵巢癌诊断中的应用 张振宇 何成章 浦 红 苏州大学附属第四医院妇瘤科(江苏 无锡) 214062 中国图书分类号 11737．31。R445 文献标识码 A 文章编号 1001．4411(2008)05-0687．02 【摘 要】 目的：对 F脱氧葡萄糖 ( F—FDG)PET显像在监测卵巢癌复发中的临床价值进行探讨。方法：对22例怀 疑复发的卵巢癌患者，行全身 F—H)G PET检查24例次，并与近期B超、CT、Mm检查结果相比较。复发诊断根据病理、血 CA125监测及随访结果确诊。结果：24例次的PET检查中。阳性13例次，阴性11例次，阳性者证实全部为复发，阴性者中，1 例CA125升高，后经随访确诊为复发。PET监测复发的准确性、灵敏度、特异性分别为95．7％、100％、91．7％。而B超、CT、 MRI检查的准确性分别为70％、85．7％、44．4％。结论：PET较其他影像学检查能更早并准确发现可疑病灶，使患者获得早发 现、早治疗的机会，是监测卵巢癌复发极有价值的方法。 【关键词】 卵巢癌复发 体层摄影术 发射计算机 诊断 Application Of 1 8 F—FDG PET imaging in diagnosis of recurrent ovarian cancer ZHANG Zhen—Yu，HE Cheng—Zhang，PU ．Department of ObstetricsGynecology；Forth Affiliated Hospital of Suzhou Unive~ity，Wuxi 214062，Jiangsu，China [Abstract] Objective：To evaluate the practice usefulness of PET imagining for detecting disease in patients with recurrent ovarian cancer,Methods：Twen￡y—three whole—body 18F—FDG PET studies were performed in 22 patients with suspected ovarian cancer．At the same time，the performance of traditional radiologie imasing(US，CT，MRI)and Ca125 measurement were used．PET results were corn— pared with the res~m of conventional imasing，which related to patholo~eal findings，Ca125 levels and clinical follow—up．Results：PET examination showed a specificity of95．7％ ，a sensitivity of 100％ ，an accuracy of91．7％ for the diagnosis of recurrent ovarian cancer during 6～85 months among 22 cases who had previously received operation and ehemothempy．The coincidence between the res~m of B— ultrasound，CT，MRI examinations and pathologic finding were 70％ ，85．7％ and 44．4％ ，respectively．Condusion：18F—FDG PET may be more accurate and ealier tO detect recurrence ofovarian cancer with negative findings oftraditional ima砻ng．It is a clinically valuable for post-—operat