LPT、阴道镜检查结合C-erbB2、nm23-H1表达早期诊断宫颈癌的临床研究.pdfVIP

· 62· 中国优生与遗传杂志2008年第16卷第2期 LPT、阴道镜检查结合C—erbB2、nm23一H1表 达早期诊断宫颈癌的临床研究 杜亚丽，原继荣，肖 兵 (哈尔滨医科大学第二附属医院，黑龙江 哈尔滨 150086) 摘 要：目的 探讨LPrr、阴道镜检查及C—erbB2、nm23一H1表达对宫颈癌 (IC)早期诊断的意义。方法 对392 例可疑患者行 IJyr、阴道镜检查及定位活检；采用免疫组化法对检出的32例IC、70例宫颈上皮内瘤样变 (CIN)和 10例 正常组织 (NE)行C—erbB2、nm23一H1检测。结果 140例LPrr异常，占35．71％；89例阴道镜检查异常，占22．70％； 102例CIN I以上，占26．o2％。CIN I以上组织中C—erbB2和nm23一H1表达依次增高，与NE比较有显著差异 (P 0．05)。结论 【用 、阴道镜检查加定位活检结合C—erbB2及nm23一H1表达可早期诊断IC。 关键词：宫颈癌；LPT；阴道镜；C—erbB2；nm23一H1 中图分类号：R737．33 文献标识码：A 文章编号：1006—9534(2008)02—0062—03 Study on significance of LPT，colposcopy and expression of C—ed~B2 and nm23一H1 in early diagnosis of cervical carcinoma1．DU Ya—f i，YUAN 一rong，XIAO Bing．(Department of Obstetrics and C07tecology，The Second Hospital Affiliated Harbin Medical University，Harbin，150086) Abstract：Objective：To detect the significance of uyI’，colposcopy and expression of C—erbB2 and nm23一H1 in early diagno- 8is of cervical carcinoma．Methods：392 cases with cervix erosion were examined by UyI’，colposcopy and biopsy；among them 32 cases with invasive carcinoma(IC)，70 cases with cervical intraepithelial neoplasia(CIN)，C—erbB2 and nm23一H1 were exam- ined the expression by immunohistochemical staining(including 10 cases of normal cervix tissues)．Results：There were 140 cases (35．71％)and 89 cases(22．70％)showed abnormal in the check of uyr and colposcopy；102 cases(26．02％)showed CIN I． Expression of C—erbB2 and nm23一H1 were increased significantly from NE，CIN and invasive cervical carcinoma(P0．05)． Conclusion：The check of UyI’．colposcopy and the expression of C—erbB2 and nm23一H1 play an important role in early diagnosis of cervical carcinoma． Key words：Cervical carcinoma；LPT；Colposcopy；C—erbB2；nm23一H1 宫颈癌严重威胁女性生命，过早性生活、性生活紊乱、 (2)阴道镜及定位活检 对所选患者采用日本产SIL- HPV感染等因素均可导致其发病率上升。目前研究表明它 KA阴道镜成像系统进行检查，观察宫