乳腺癌组织中menaher-2蛋白的表达和意义-第三军医大学学报.docVIP

Mena、Her-2蛋白在乳腺癌组织中的表达和意义 张青山，徐正顺2，郑海燕1 (1.河南科技大学医学院，洛阳 471003；2.郑州大学基础医学院，郑州 450052) [摘要] 目的：探讨乳腺癌组织中Mena和Her-2蛋白的表达和意义。方法：用免疫组化SP法检测60例乳腺癌组织和15例正常乳腺组织中Mena和Her-2蛋白的表达，同时分析其与临床病理资料的关系。结果：Mena蛋白在乳腺癌组织中的阳性表达率为73.3% (44/60) ,Her-2蛋白在乳腺癌组织中的阳性表达率为38.3% (23/60)，均显著高于在正常乳腺组织中的表达(P0.05)，并且都与临床分期及腋淋巴结转移密切相关(P0.05)，与患者年龄、肿瘤大小、ER、PR无明显相关性(P0.05)。Mena和Her-2蛋白的表达具有显著相关性(P0.05)。结论：Mena和Her-2可能在乳腺癌细胞的浸润和转移中起重要作用。检测Mena和Her-2蛋白的表达有可能对判断乳腺癌的恶性程度、浸润转移潜能及预后判断有重要参考价值。 [关键词] 乳腺癌; Mena ;Her-2 ;免疫组织化学 [中图分类号] R737.9 [文献标识码] A Expressions and significance of Mena and Her-2 protein in breast cancer Zhang Qingshan1, Xu Zhengshun2, Zheng Haiyan1( 1.Medical College , Henan University of Science and Technology, Luoyang 471003，China; 2.Basic Medical College,Zhengzhou University, Zhengzhou 450052, China) [Abstract] Objective：ethods：Results：the positive expression of Her-2 protein was detected in 23(38.3%) of the 60 tumors, the ex- pressions of Mena and Her-2 protein in breast cancer were significantly higher than in normal breast tissues(P0.05) and were positively correlated to clinical stage and armpit lymph node metastasis(P0.05),but not to patient age,tumorsize , estrogen receptor(ER) and progesterone receptor (PR) expressions (P0.05). The expression of Mena protein was positively correlated to the expression of Her-2 protein (P0.05). Conclusion：he positive expressions of Mena and Her-2 protein in breast cancer were importantly related to breast cancer infiltration and metastasis.Detection of Mena and Her-2 protein may have important reference value in determining the degree of malignancy,the invasive and metastatic potential and evaluating prognosis. [Key words] Breast cancer ;Mena ;Her-2 ;Immunohistochemistry Correspondence to: Xu Zhengshun (徐正顺),Tel: (0379E-mail: xuzhengshun66@163.com 乳腺癌是女性最常见的恶性肿瘤之一，常转移至肺、骨、脑等部位，严重危害女性的身心健康。相关基因的检测对指导临床治疗、判断预后具有非常重要的价值。Mena蛋白是Ena/VASP（Enabled/Vasodilator-stimulated Phosphoprotein）家族中重要的一员，国外文献报道[1]：Mena能够促进乳腺癌细胞的浸润和转移。经查新：目前国内