中药芪参复康对焦虑模型大鼠 ep及细胞因子的影响（Effects of Chinese herbal medicine Qi Fu Kang on EP and cytokines in anxiety model rats）.doc

中药芪参复康对焦虑模型大鼠 ep及细胞因子的影响（Effects of Chinese herbal medicine Qi Fu Kang on EP and cytokines in anxiety model rats） Effects of Chinese herbal medicine Qi Fu Kang on beta EP and cytokine in anxiety model rats This article source: paper / [Abstract] Objective: to traditional Chinese medicine QiShenFuKang capsule (qsfk) anti anxiety effects of nerve? Immune regulation mechanism. Methods: the elevated crossmaze International (EPM) animal models of anxiety, with Ding Luohuan ketone (bus) as control, the effects of qsfk on EPM rats serum EP, beta? No, IL? 1 beta, IL? 6 and TNF alpha effect. Results: compared with the model group, qsfk and bus can reduce the plasma beta EPM rats? The content of EP (p 0.01), had no obvious effect on hypothalamic beta? EP level; but the two groups can increase the EPM anxiety model rats the serum levels of no (p 0.05); qsfk can increase the serum IL of EPM rats? 1 beta and TNF alpha level of IL? 6 has no obvious effect on content; serum cytokine levels of bus did not change the anxiety model rats. Conclusion: qsfk decreased plasma beta EP content, increase the serum NO? The concentration of serum IL and EPM 1 beta? And TNF alpha levels to modulate the immune disorder in the anxiety state Keyword: Shenqi Fukang capsule cross maze model, beta endorphin, nitric oxide, cytokines, anxiety 0 Introduction QiShenFuKang capsule (QiShenFuKang, qsfk) is mainly used for clinical treatment of liver blood deficiency, blood Yangxin, deficiency of heat disturbance of dysphoria can not sleep anxiety caused by prescription. The experimental results show that the spontaneous activity of qsfk capsule can increase the animal, enhance its strength, and can change the reverse force of cold water swimming stress caused by adrenal VitC content of 1, shows that the preparation has anti stress and anti anxiety effects. We used anxiety animal model elevated crossmaze Universal International (the elevated plus maze? Test, EPM, qsfk) was observed in EPM rat beta endorphin