阿德福韦酯治疗老年慢性乙肝患者的安全性及疗效 张海燕.PDFVIP

2010 12 28 9 6 Chin J Mult Organ Dis Elderly, Vol.9, No. 6, De 28, 2010 # 50 1 # # # 吉英杰, 张文瑾, 范振平, 罗生强, 蔡少平, 高 峰, 张海燕 = 65 2006 10 2009 10 30 65 , 60 65 , , 10 mg/ d, , 4812243648 HBV DNA 48 76% ( 13/ 17) 80% ( 28/ 35) , H BV DNA 83% ( 25/ 30) 73% ( 44/ 60) , ( 78 ? 73) d ( 69? 53) d, H BV DNA ( 124 ? 75) d ( 145 ? 76) d, ( P 0. 05) , 48 , 2 , 1 , = ; , ; = R512. 6+ 2 = A = 167 1-5403( 2010) 06-0501-04 Adefovir dipivoxil for treatment of elderly patients with chronic hepatitis B JI Yingj ie, ZH A N G Wenj in, FA N Zhenp ing , et al L iver Disease Center f or M ilitar S taf f , Chinese PLA 302nd H osp ital, Beij ing 100039, China = Abstract Obje t ive T o evaluate the effi a y and safety of adefovir dipivoxil for elderly patients ( age \65 years) with hroni hepat itis B. Methods Ninety pat ients with hroni hepatit is B w ere divided into two groups: the elderly group ( 30 ases, age \65 years) and the non-elderly group ( 60 ases, age 65 years) . All subje ts re eived oral administration of adefovir dipivoxil ( 10 mg/ d) . The laboratory data, su h as the hepati fun tions, serum HBV DNA levels, renal fun tion, glu ose, total holesterol and blood routine indi es, w ere om pared between the tw o groups before and at 4, 8, 12, 24, 36, 48 w eeks after adefovir dipivox il administration. Results At 48 w eeks after adefovir dipivox il administ ration, the normalization rates of hepati fun tion in elderly group and non-elderly group were 76% ( 13/ 17) and 80% ( 28/ 35)