行为异常型额颞叶痴呆研究进展.PDF

中国现代神经疾病杂志 年 月第 卷第 期 2015 7 15 7 ChinJContempNeurolNeurosurg,July2015,Vol.15,No.7 ·531 · 专题综述 · · 行为异常型额颞叶痴呆研究进展 顾小花 徐俊 【摘要】 鉴于我国目前尚无额颞叶痴呆的流行病学资料，行为异常型额颞叶痴呆国际标准联盟公 布的新的诊断标准与我国专家共识、多模态影像学和生物学标志物研究有望提高临床对行为异常型额 颞叶痴呆的认识，多种干预措施可能延缓病情进展。 【关键词】 痴呆； 额叶； 颞叶； 生物学标记； 综述 Researchprogressof behavioralvariant frontotemporaldementia GUXiao⁃hua,XUJun1 2 1Intensive Care Unit, 2Department of Neurology, Northern Jiangsu Peoples Hospital, Yangzhou 225001, Jiangsu, China Corresponding author: XU Jun (Email: 126.com) 【 】 Abstract There is no epidemiological data of frontotemporal dementia (FTD) in China. The applicationofupdateddiagnosticcriteria,publishingoffrontotemporallobardegeneration(FTLD)consensus in China, development of multimodal imaging and biomarkers promote the clinical understanding on behavioralvariantfrontotemporaldementia(bvFTD). ThereisstillnodrugstreatingFTDapprovedbyU.S. FoodandDrugAdministration(FDA). MultidisciplinaryinterventionmaydelaytheprogressionofbvFTD. 【 】 Keywords Dementia; Frontal lobe; Temporal lobe; Biologicalmarkers; Review This study was supported by Major New Drugs Innovation and Development Project of Ministry of Science and Technology (No. 2012ZX09303-003, 2012Z002), National Natural Science Foundation of China (No., Science and Technology Support Project of Jiangsu Province (No. BE2011614), Open Project of Key Laboratory of Jiangsu Province (No. SJ11KF05), Ⅲ Jiangsu Province 333 High⁃Level Talents Third Level [No. (2013) -0077], Six Peaks of Talents Support Program of Jiangsu Province (No. 2012-WS-002) and Lü Yang Jin Feng