A novel risperidone-loaded SAIB–PLGA mixture matrix depot with a reduced burst release_ effects.pdfVIP

J Mater Sci: Mater Med (2012) 23:443–455 DOI 10.1007/s10856-011-4521-2 A novel risperidone-loaded SAIB–PLGA mixture matrix depot with a reduced burst release: effects of solvents and PLGA on drug release behaviors in vitro/in vivo Xia Lin • Shenshen Yang • Jingxin Gou • Mingming Zhao • Yu Zhang • Na Qi • Haibing He • Cuifang Cai • Xing Tang • Penghong Guo Received: 28 August 2011 / Accepted: 6 December 2011 / Published online: 15 December 2011 Springer Science+Business Media, LLC 2011 Abstract The purpose of this study was to develop an in to