Pax2,增殖细胞核抗原,细胞凋亡在肾病综合征激素耐药中的作用.PDF

维普资讯 蛳 第2l卷第l7期2oo6年9月 JApplClinPedinf，。yof．21№．17．Sep．2006 · 1139 · · 论 著 · Pax2、增殖细胞核抗原、细胞 凋亡在 肾病综合征 激素耐药中的作用 张慧琼 ，易著文 ，何小解 (1．广东医学院附属医院儿科，广东湛江 524001；2．中南大学湘雅二医院 儿科，长沙 4l00l1) EffectsofPaired Box2，Proliferation CellNuclearAntigen and CellApoptosisin Nephrotic Syndrome with Steroid—Resistance ZHAN(；Hui qiong’，YIZhu u HE Xiao—J ， (1DepartmentofPediatrics，theAffiliatedH(xspitalofGuangdongMedicalCollege，Zhanjiang52400I，China；2．1)e1)armlentofPedia— trics，theSecondH(xspitalofXiangya，(~ntralSouthUniversity．Chnagsha410011，China) D Abstract：Objective Foinvestigatetheexpressionofpairedb()x2(Pax2)，proliferationcellnuclearantigen(I)(、NA)andcellalx)pto sisinsteroid s,ensitiveandsteroid resistnatgroupswithprimarynephroticsyndrome(PNS)andt)【findouttheactionofPax2exprcs— sioninPNSwithsteroid resistance．Method TheexpressionsofPax2，P(NA wereevaluatedbyimmunohistcxhemistryandcellapopto— D isbyfluorescencemiocscnpe Results Pax2expre．,asioninrenaltubulehadapositivecorrelationwithPCNA exprexsioninsteroid sensi— tivegroup．Insteroid resistantgroup，Pax2expressionhadnocorrelationwithPCNA．Pax2hadanegativeocrrelationwithcellatx)pto— sis．Conclusions Pax2properexpressionfacilitatePCNA expre．ksionnadrepairtubulointerstitiallesionsinsteroid—sensitivegroup．Renal C tubularepithelialcellprolifcrationccxordinatcdwithcellapo ptosisPax2o