芪丹通脉片对犬心肌耗氧量的影响.docVIP

　　芪丹通脉片对犬心肌耗氧量的影响 ：马静，王宗仁，马世平，行利，李晶华，肖铁卉，郑谨，龙铟，马爱玲 【关键词】 芪丹通脉片 　　【Abstract】 AIM: To study the effects of Qidantongmai tablet (QDTMT) on the amount of myocardial oxygen consumption in dogs. METHODS: Dogs ly into control, (QDTMT) high dosage (QDTMTH), lo groups. The blood oxygen content of coronary arteries and veins easured by hemoxmeter. Myocardial oxygen consumption and utility ratio of myocardial oxygen ount of oxygen in coronary arteries that of control group 60min after the administration of QDTMT ［ (124.2±25.4 ) vs (968±40), (137.1±15.1) vs (99.9±2.4), (137.4±12.6) vs (943±28) g#12539;L-1, Plt;0.01］. Myocardial oxygen consumption that of the control 45 min after the administration of QDTMT. ［(74.5±14) vs (94.6±11.5), (76.0±17.3) vs (90.6±11.5), (76.9±10.4) vs (90.6±5.5), (74.6±16.7) vs (95.0±4.9) mL#12539;min-1, Plt;0.05］. In QDTMTL group and QDTMH groups, the utility ratio of myocardial oxygen that of the control after 60 min the administration of QDTMT ［(84.9±8.0) vs (98.0±6.6), (84.6±6.3) vs (94.6±4.3), (82.4±7.5) vs (99.9±6.6) %, Plt;0.05］. CONCLUSION: QDTMT can ameliorate myocardial ischemia by reducing the amount of myocardial oxygen consumption and the utility ratio of myocardial oxygen. 　　【Keyai tablet; myocardial oxygen consumption; oximetry 　　【摘要】 目的： 探讨芪丹通脉片（QDTMT）对犬心肌耗氧量的影响. 方法： 将实验犬随机分为空白对照组（Control）、QDTMT大剂量组(QDTMTH)、QDTMT小剂量组(QDTMTL)及阳性对照组(Diltiazem). 用血氧测定仪测定冠状动、静脉血氧含量，计算心肌耗氧量，氧利用率. 结果： 给药60 min后，QDTMTH动脉血氧含量降低，与Control相比有显著性差异［ (124.2±25.4 ) vs (968±40), (137.1±15.1) vs (99.9±2.4)和 (137.4±12.6) vs (943±28) g#12539;L-1, Plt;0.01］. 给药45 min后，QDTMTL心肌耗氧量显著低于Control ［(74.5±14) vs (94.6±11.5), (76.0±17.3) vs (90.6±11.5), (76.9±10.4) vs (90.6±5.5)和(74.6±16.7) vs (95.0±4.9) mL#12539;min-1, Plt;0.05］. QDTMTH、QDTMTL的心肌氧利用率均下降；60 min后，与Control相比有显著性差异［(84.9±8.0) vs (98.0±6.6), (84.6±6.3) vs (94.6±4.3)和(82.4±7.5) vs (99.9±6.6) %, Plt;0.05］. 结论： QDTMT可通过降低心肌耗氧量，降低氧利用率，改善心肌缺血. 　　【关键词】 芪丹通脉片；心肌耗氧量；血氧测定 　　0引言 　　氧代谢失调是心肌缺血的基本病理过程，心肌耗氧量是影响心肌氧代谢的重要因