双水平气道正压通气治疗重叠综合征患者血气分析及肺功能疗效.docVIP

双水平气道正压通气治疗重叠综合征患者血气分析及肺功能疗效 　　摘要：目的探讨双水平气道正压通气治疗重叠综合征（慢性阻塞性肺疾病患者合并阻塞性睡眠呼吸暂停低通气综合征）患者血气分析及肺功能的疗效观察。方法 选取78例重叠综合征患者分为两组，研究组及对照组，研究组在给予抗感染、平喘、吸氧综合治疗基础上给予无创双水平正压通气，对照组给予抗感染、平喘、吸氧综合治疗，监测肺功能及血气分析数据。结果 研究组和对照组在血气分析包括动脉血二氧化碳分压（PaCO2）、动脉血氧分压（PaO2）、血氧饱和度等方面差异有统计学意义（P0.05）。肺功能指标FVC、FVC占预计值%，PEF、FEV1占预计值%、FEV1/FVC%占预计值%明显改善（P0.05）。结论 双水平气道正压通气治疗重叠综合征患者可以改善患者缺氧状况及肺功能，可作为重叠综合征患者的第一线治疗方案。 　　关键词：慢性阻塞性肺疾病；阻塞性睡眠呼吸暂停低通气综合征；无创双水平正压通气 　　Abstract：Objective To investigate the efficacy of bi-level positive airway pressure ventilation in the treatment of patients with overlapping syndrome （chronic obstructive pulmonary disease with obstructive sleep apnea hypopnea syndrome）.Methods 78 patients with overlapping syndrome were divided into two groups.The study group and the control group were treated with noninvasive bi-level positive pressure ventilation on the basis of anti-infection，antiasthmatic and oxygen comprehensive therapy.The control group was given anti-Asthma，oxygen comprehensive treatment，monitoring of lung function and blood gas analysis data.Results The difference between the study group and the control group was statistically significant（P 0.05）in blood gas analysis including arterial carbon dioxide partial pressure（PaCO2），arterial oxygen pressure（PaO2），and oxygen saturation.Pulmonary function index FVC，FVC accounted for the expected value%，PEF，FEV1 accounted for the expected value%，FEV1/FVC% of the expected value of significant improvement （P 0.05）.Conclusion Double - level positive airway pressure in patients with overlapping syndrome can improve the hypoxia and pulmonary function of patients，and can be used as the first-line treatment of patients with overlapping syndrome. 　　Key words：Chronic obstructive pulmonary disease；Obstructive sleep apnea hypopnea syndrome；Noninvasive bi-level positive pressure ventilation 　　慢性阻塞性肺疾病（COPD）是一种以阻塞性通气功能障碍为特点、慢性进行性加重性疾病。阻塞性睡眠呼吸暂停低通气综合症（OSAHA）的特点是睡眠期间反复出现的部分或完全的上气道阻塞事件，往往导致缺氧和二氧化碳逐渐增加；上述两种疾病同时存在被称为“重叠综合征”[1]，较单纯阻塞性眠呼吸暂停低通气综合征患者及气道阻塞程