aqueous extracts of dried fruits of zanthoxylum armatum dc., (rutaceae) induce cellular and nuclear damage coupled with inhibition of mitotic activity in vivo水提取花椒armatum dc的干果。.pdfVIP

下载本文档

1
0
约5.64万字
约 8页
2017-08-27 发布于上海
举报
版权申诉

aqueous extracts of dried fruits of zanthoxylum armatum dc., (rutaceae) induce cellular and nuclear damage coupled with inhibition of mitotic activity in vivo水提取花椒armatum dc的干果。.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

aqueous extracts of dried fruits of zanthoxylum armatum dc., (rutaceae) induce cellular and nuclear damage coupled with inhibition of mitotic activity in vivo水提取花椒armatum dc的干果。

American Journal of Plant Sciences, 2012, 3, 1646-1653 /10.4236/ajps.2012.311200 Published Online November 2012 (http://www.SciRP.org/journal/ajps) Aqueous Extracts of Dried Fruits of Zanthoxylum armatum DC., (Rutaceae) Induce Cellular and Nuclear Damage Coupled with Inhibition of Mitotic Activity in Vivo Eros Vasil Kharshiing Department of Botany, St. Edmund’s College, Shillong, India. Email: eros.kharshiing@ Received August 9th, 2012; revised September 12th, 2012; accepted October 15th, 2012 ABSTRACT Bioactive compounds derived from plant natural compounds have proven to be valuable sources of metabolites which can seldom be obtained from other sources. Plants belonging to the genus Zanthoxylum have been valued across various cultures for their curative properties. Zanthoxylum armatum DC., belonging to the family Rutaceae is extensively used in traditional practices in North-Eastern India and neighbouring regions including South-East Asia. However, the poten- tial cytogenetic effects of Zanthoxylum armatum under in vivo conditions, and their causative mechanisms have not yet been studied in detail. The current study was undertaken to evaluate the cytotoxic and genotoxic potential of aqueous extracts of fruits of Z. armatum under in vivo conditions using the Allium test. Physiological and cellular data indicate that the extracts induce clumped chromosomes at metaphase stage of cell division coupled with mitotic arrest. Electron microscopy data reveal membrane damage of cellular organelles, chromatin condensation and chromatin marginalisa- tion in cell of roots incubated in the extracts. The extracts also induce concentration dependent protein precipitation and genomic DNA degradation. Keywords: Clumped Chromosomes; Chromatin Condensation and Marginalisation; TEM; Toxicity; Zanthoxylum armatum 1. Introduction of diseases in humans and animals [8-11]. Extracts of Z.