原创力文档associations between high-sensitivity c-reactive protein and membrane fluidity of red blood cells in hypertensive elderly men an electron spin resonance study高敏c反应蛋白之间的关联和膜流动性高血压老年男性红细胞的电子自旋共振研究.pdfVIP
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associations between high-sensitivity c-reactive protein and membrane fluidity of red blood cells in hypertensive elderly men an electron spin resonance study高敏c反应蛋白之间的关联和膜流动性高血压老年男性红细胞的电子自旋共振研究
Hindawi Publishing Corporation
International Journal of Hypertension
Volume 2012, Article ID 292803, 5 pages
doi:10.1155/2012/292803
Clinical Study
Associations between High-Sensitivity
C-Reactive Protein and Membrane Fluidity of
Red Blood Cells in Hypertensive Elderly Men:
An Electron Spin Resonance Study
Kazushi Tsuda1, 2
1 Cardiovascular and Metabolic Research Center, Kansai University of Health Sciences, Senn-nann-gunn, Kumatori-cho,
Wakaba 2-11-1, Osaka 590-0482, Japan
2 Division of Cardiology, School of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
Correspondence should be addressed to Kazushi Tsuda, tsudak@mail.wakayama-med.ac.jp
Received 2 June 2011; Accepted 13 October 2011
Academic Editor: Blas Gil Extremera
Copyright © 2012 Kazushi Tsuda. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Recent evidence indicates that high-sensitivity C-reactive protein (hs-CRP), an acute phase of an inflammatory marker, might be
associated with atherosclerosis, hypertension, and other cardiovascular diseases. The present study was performed to assess the
possible link between plasma hs-CRP and membrane fluidity (a reciprocal value of membrane microviscosity) in hypertensive
elderly men. We measured the membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive elderly men using
an electron spin resonance and spin-labeling method. Membrane fluidity of RBCs was decreased in hypertensive elderly men
compared with normotensive elderly men. Plasma hs-CRP levels were significantly higher in hypertensive elderly men than in
normotensive elderly men. In contrast, plasma nitric-oxide- (NO-
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