原创力文档an efficient and convenient synthesis of certain 2-thioxothiazole,2-oxo-1,2-dihydropridine, 2-oxo-2h-pyran,2,4-diaminothiophene and pyrazolo[5,1-c][1,2,4]triazine derivatives containing antipyrine moiety英文论文.pdfVIP
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an efficient and convenient synthesis of certain 2-thioxothiazole,2-oxo-1,2-dihydropridine, 2-oxo-2h-pyran,2,4-diaminothiophene and pyrazolo[5,1-c][1,2,4]triazine derivatives containing antipyrine moiety英文论文
International Journal of Organic Chemistry, 2012, 2, 135-142
/ 10.4236/ijoc.2012.22021 Published Online June 2012 (http://www.SciRP.org/journal/ijoc)
An Efficient and Convenient Synthesis of Certain
2-Thioxothiazole,2-oxo-1,2-dihydropridine,
2-Oxo-2H-pyran,2,4-diaminothiophene and
Pyrazolo[5,1-c][1,2,4]triazine Derivatives Containing
Antipyrine Moiety
1,2 2* 2
Seif-Eldin Nasr Ayyad , Fathy Muhammad Abdelaziz El-Taweel , Abdel-Ghani Ali Elagamey ,
Tahani Mahmoud El-Mashad2
1Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, KSA
2Department of Chemistry, Faculty of Science, New Damietta Branch, Mansoura University, New Damietta, Egypt
*
Email: fathyeltaweel@
Received February 18, 2012; revised March 9, 2012; accepted March 23, 2012
ABSTRACT
2-Thioxothiazole derivatives 5a-c were prepared by reacting a mixture of 1a-c, CS /KOH and 4-(2-chloroacetyl)-1,
2
5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (3). Reacting 2-cyano-N-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-
pyrazol-4-yl)-2-thioxothiazol-3(2H)-yl)acetamide (5c) with mercaptoacetic acid, arylidenemalononitriles 8 and (E)-
3-(dimethylamino)-1-(furan-2-yl)prop-2-en-1-one (12) give 4-oxo-4,5-dihydrothiazole 6, 2-oxo-1,2-dihydropyridine 10
and 2-oxo-2H-pyran 15 respectively. Heating a mixture of 5c, malononitrile and elemental sulfur yiel
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