associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men an electron spin resonance investigation英文论文.pdfVIP
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associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men an electron spin resonance investigation英文论文
Advances in Bioscience and Biotechnology, 2012, 3, 1020-1027 ABB
/10.4236/abb.2012.327124 Published Online November 2012 (http://www.SciRP.org/journal/abb/)
Associations of oxidative stress and inflammation and their
role in the regulation of membrane fluidity of red blood
cells in hypertensive and normotensive men: An electron
spin resonance investigation
Kazushi Tsuda1,2
1Cardiovascular and Metabolic Research Center, Kansai University of Health Sciences, Osaka, Japan
2Division of Cardiology, Department of Medicine, Wakayama Medical University, Wakayama, Japan
Email: tsudak@mail.wakayama-med.ac.jp
Received 19 August 2012; revised 27 September 2012; accepted 13 October 2012
ABSTRACT rheologic behavior of RBCs and microcirculatory
dysfunction in hypertensive men.
There is evidence showing that increased levels of
oxidative stress and C-reactive protein (CRP) might
Keywords: Oxidative Stress; 8-Iso-Prostaglandin F2α;
be associated with obesity, hypertension, atheroscle-
High-Sensitivity C-Reactive Protein; Nitric Oxide;
rosis and other cardiovascular diseases. This study
Membrane Fluidity; Electron Spin Resonance;
was undertaken to investigate possible relationships
Hypertension
among plasma 8-iso-prostaglandin F2α (8-iso-PG F2α:
an index of oxidative stress), high-sensitivity (hs)-
CRP and membrane fluidity (a reciprocal value of
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