axillary recurrences after sentinel node surgery—results over ten years in a university hospital腋窝前哨淋巴结后复发surgery-results十多年在大学医院.pdfVIP

Journal of Cancer Therapy, 2012, 3, 846-852 /10.4236/jct.2012.325108 Published Online October 2012 (http://www.SciRP.org/journal/jct) Axillary Recurrences after Sentinel Node Surgery—Results over Ten Years in a University Hospital 1 2 3 4 1,5 Helle Eilertsen , Ellen Schlichting , Marianne Efskind Harr , Daehoon Park , Torill Sauer , Siri Larønningen6, Rolf Kaaresen1,2* 1Medical Faculty, University of Oslo, Oslo, Norway; 2Department of Breast and Endocrine Surgery, Oslo University Hospital, Oslo, 3 4 Norway; Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Department of Pathology, Vestre Viken Hospital, Drammen, Norway; 5Department of Pathology, Oslo University Hospital, Oslo, Norway; 6Cancer Registry of Norway, Oslo, Norway. * Email: rolf.karesen@medisin.uio.no Received July 10th, 2012; revised August 15th, 2012; accepted August 27th, 2012 ABSTRACT Background: Sentinel node biopsy (SNB) was introduced at Ullevaal University Hospital in 2000. This article presents results from the first ten years use of the method. Material and Methods: A prospective registration of 2762 patients was made from 2000 through 2009. Results: The median follow-up time was 51 months. The overall detection rate was 93%. 36% of the patients with positive SNs had non-sentinel metastases. These were significantly associated with a macrometastatic SN and a primary tumour 20 mm. 18% of patients with sentinel metastasis ≤ 2 mm had non-sentinel metastases. 14 patients with negative SN (0.7%) developed axillary recurrence. 32% with a preoperative diagnosis of ductal carcinoma in situ (DCIS) were upstaged to infiltrating carcinoma on final histology. None of the patients with pure DCIS had