b-cell response during protozoan parasite infectionsb细胞反应在原生动物寄生虫感染.pdfVIP

Hindawi Publishing Corporation Journal of Parasitology Research Volume 2012, Article ID 362131, 8 pages doi:10.1155/2012/362131 Review Article B-Cell Response during Protozoan Parasite Infections ´ Marıa C. Amezcua Vesely, Daniela A. Bermejo, Carolina L. Montes, ´ Eva V. Acosta-Rodrıguez, and Adriana Gruppi Centro de Investigaciones en Bioquımica Clınica e Inmunologıa (CIBICI-CONICET), Departamento de Bioquımica Clınica, ´ ´ ´ ´ ´ Facultad de Ciencias Quımicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, ´ ´ 5000 Cordoba, Argentina ´ Correspondence should be addressed to Adriana Gruppi, agruppi@.ar Received 31 August 2011; Accepted 6 October 2011 Academic Editor: Mauricio M. Rodrigues ´ Copyright © 2012 Marıa C. Amezcua Vesely et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies spe