cancertestis antigen mage-c1ct7 new target for multiple myeloma therapycancertestis抗原mage-c1ct7多发性骨髓瘤治疗的新目标.pdfVIP

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cancertestis antigen mage-c1ct7 new target for multiple myeloma therapycancertestis抗原mage-c1ct7多发性骨髓瘤治疗的新目标.pdf

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cancertestis antigen mage-c1ct7 new target for multiple myeloma therapycancertestis抗原mage-c1ct7多发性骨髓瘤治疗的新目标

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 257695, 7 pages doi:10.1155/2012/257695 Review Article Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy 1 ´ 2 1 Fabricio de Carvalho, Andre L. Vettore, and Gisele W. B. Colleoni 1 Disciplina de Hematologia e Hemoterapia, Universidade Federal de Sao Paulo, UNIFESP/EPM, Rua Botucatu, ˜ 04023-900 Vila Clementino, SP, Brazil 2 Departamento de Ciencias Biologicas, UNIFESP, 09972-270, Diadema, SP, Brazil ˆ ´ Correspondence should be addressed to Fabricio de Carvalho, fcarvalho@unifesp.br Received 4 November 2011; Accepted 28 December 2011 Academic Editor: Mohamad Mohty Copyright © 2012 Fabricio de Carvalho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells). Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy. CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-speciﬁc. Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been d