原创力文档cervical cancer screening hterc gene amplification detection by fish in comparison with conventional methods宫颈癌筛查hterc基因扩增检测与常规方法相比,鱼.pdfVIP
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cervical cancer screening hterc gene amplification detection by fish in comparison with conventional methods宫颈癌筛查hterc基因扩增检测与常规方法相比,鱼
Open Journal of Obstetrics and Gynecology, 2012, 2, 11-17 OJOG
/10.4236/ojog.2012.21003 Published Online March 2012 (http://www.SciRP.org/journal/ojog/)
Cervical cancer screening: hTERC gene amplification
detection by FISH in comparison with conventional
methods
1 1* 2
Qisang Guo , Long Sui , Youji Feng
1Medical Center for Diagnostics Treat of Cervical Disease, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
2Department of Obstetrics and Gynecology, First People’s Hospital, Shanghai Jiao Tong University, Shanghai, China
*
Email: suilong@
Received 20 November 2011; revised 30 December 2011; accepted 10 January 2012
ABSTRACT under the curve = 0.857) compared to HPV test (area
under the curve = 0.717) and cytology(area under the
Aim: To assess the clinical significance of hTERC
curve = 0.777) to discriminate HSIL or higher from
amplification for cervical cancer screening detected
LSIL or lower. This study also found a significant
by fluorescence in situ hybridization (FISH) and
positive correlation between positive hTERC gain
compare it with that of current screening methods
and HR-HPV infection, abnormal cytological or his-
within the same group. Methods: A total of one hundred
t
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