原创力文档brucella spp. lumazine synthase as a novel immunomodulator to produce egg yolk antibodies布鲁氏菌spp。lumazine合酶作为一种新颖的免疫调制剂生产蛋黄抗体.pdfVIP
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brucella spp. lumazine synthase as a novel immunomodulator to produce egg yolk antibodies布鲁氏菌spp。lumazine合酶作为一种新颖的免疫调制剂生产蛋黄抗体
Advances in Bioscience and Biotechnology, 2012, 3, 80-86 ABB
/10.4236/abb.2012.31012 Published Online February 2012 (http://www.SciRP.org/journal/abb/)
Brucella spp. Lumazine synthase as a novel
immunomodulator to produce egg yolk antibodies
1 1 1 1 2
Demian Bellido , Pablo Chacana , Marina Mozgovoj , Diego Gonzalez , Fernando Goldbaum ,
Andrés Wigdorovitz1, María José Dus Santos1
1Institute Instituto de Virología, INTA Castelar, Hurlingham, Argentina
2Fundación Instituto Leloir, Buenos Aires, Argentina
Email: dbellido@.ar
Received 12 October 2011; revised 22 November 2011; accepted 28 December 2011
ABSTRACT This strategy has demonstrated to be successful in the
treatment and prophylaxis of diseases caused by bacteria,
Lumazine synthase from Brucella spp. (BLS) is a
viruses or even parasites [2]. However, large scale pro-
highly immunogenic decameric protein. It has been
duction of mammalian antibodies is expensive and un-
previously described as a carrier of peptides or pro-
easy. To overcome these difficulties, egg yolk antibodies
teins to increase their immunogenicity in different
are proposed as a low-cost and feasible alternative [3].
animal species, but its activity has never been evalu-
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