bronchial hyperreactivity pathogenesis and treatment options支气管代发病机理和治疗选择.pdfVIP

Open Journal of Molecular and Integrative Physiology, 2011, 1, 43-51 OJMIP doi:10.4236/ojmip.2011.13007 Published Online November 2011 (http://www.SciRP.org/journal/ojmip/). Bronchial hyperreactivity: pathogenesis and treatment options Martina Antosova1 1 2 , Anna Strapkova , Jana Plevkova 1Comenius University in Bratislava, Jessenius School of Medicine in Martin, Department of Pharmacology, Martin, Slovakia; 2Comenius University in Bratislava, Jessenius School of Medicine in Martin, Department of Pathophysiology, Martin, Slovakia. Email: antosova@jfmed.uniba.sk; jplevkova@ Received 21 July 2011; revised 14 September 2011; accepted 12 October 2011. ABSTRACT 2. RISK FACTORS FOR DEVELOPMENT OF BRONCHIAL HYPERREACTIVITY This review is written to summarize and critically analyze pathogenesis of bronchial hyperreactivity The main risk factors in the pathogenesis of the BHR are (BHR) as an underlying outcome for suitable treat- genetic predisposition, atopy, age, gender, smoking and inhalation of chemical irritants. It had been identified ment options. It describes and discusses the role of genetic predisposition, inflammatory mediators and that BHR is more common in subjects with allergic other endogenous factors (growth factors, nuclear rhinitis and patients who are sensitive to pollen and transcription factors), neural regulation and pro- house dust. However, not all atopic subjects had