chitosan sub-micron particles prepared using sulfate ion salt as bacteriostatic materials in neutral ph condition壳聚糖亚微米粒子准备使用硫酸盐离子盐作为抑菌材料在中性ph值条件.pdfVIP

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chitosan sub-micron particles prepared using sulfate ion salt as bacteriostatic materials in neutral ph condition壳聚糖亚微米粒子准备使用硫酸盐离子盐作为抑菌材料在中性ph值条件.pdf

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chitosan sub-micron particles prepared using sulfate ion salt as bacteriostatic materials in neutral ph condition壳聚糖亚微米粒子准备使用硫酸盐离子盐作为抑菌材料在中性ph值条件

Journal of Biomaterials and Nanobiotechnology, 2011, 2, 347-352 347 doi:10.4236/jbnb.2011.24043 Published Online October 2011 (http://www.SciRP.org/journal/jbnb) Chitosan Sub-Micron Particles Prepared Using Sulfate Ion Salt as Bacteriostatic Materials in Neutral pH Condition 1,2 2,3* 2,3 2,3 2 Kanako Saita , Shoji Nagaoka , Maki Horikawa , Tomohiro Shirosaki , Shigeki Matsuda , Hirotaka Ihara1,3* 1Department of Applied Chemistry and Biochemistry, Kumamoto University, Kumamoto, Japan; 2Kumamoto Industrial Research Institute, Kumamoto, Japan; 3Kumamoto Institute for Photo-Electro Organics, Kumamoto, Japan. * Email: ihara@kumamoto-u.ac.jp, nagaoka@kmt-iri.go.jp Received June 4th, 2011; revised July 22nd, 2011; accepted September 5th, 2011. ABSTRACT In this paper, the newly developed ion exchange phase separation method to create chitosan sub-micron particles is introduced: 1) chitosan was dissolved in a lactic acid aqueous solution; 2) the obtained chitosan solution was added stepwise in a sodium sulfate aqueous solution and cooled down to 5 ˚C to become slightly turbid through agglutination; 3) desalinating and deacidifying of the mixture was carried out by a dialyzing tube method. IR spectroscopy and ele- mental analysis indicated that the agglutination of chitosan was induced by crosslinking effect with an electrostatic interaction between sulfate anions and amino groups in the glucosamine unit although large excess of Na SO caused 2 4 undesirable further agglutination of the resultant chitosan particles. As a result,