clinical application of development of nonantibiotic macrolides that correct inflammation-driven immune dysfunction in inflammatory skin diseases临床应用的发展nonantibiotic大环内酯类,正确inflammation-driven免疫功能紊乱在炎症性皮肤病.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 563709, 16 pages doi:10.1155/2012/563709 Review Article Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases Carmen Rodriguez-Cerdeira,1 Elena Sanchez-Blanco,2 and Alberto Molares-Vila3 1 Dermatology Department, CHUVI and University of Vigo, Vigo, Spain 2 University of Vigo, Vigo, Spain 3 Analytical Chemistry Department, University of Vigo, Vigo, Spain Correspondence should be addressed to Carmen Rodriguez-Cerdeira, crodcer@uvigo.es Received 18 February 2012; Revised 20 July 2012; Accepted 22 July 2012 Academic Editor: Kazuhito Asano Copyright © 2012 Carmen Rodriguez-Cerdeira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Inflammation-driven immune dysfunction supports the development of several chronic human disorders including skin diseases. Nonantibiotic macrolides have anti-inflammatory and/or immunomodulatory activity that suggests the exploitation of these in the treatment of skin diseases characterized by inflammatory disorders. Materials and Methods. We performed an extensive review of the nonantibiotic macrolide literature published between 2005 and 2012, including cross-references of any retrieved articles. We also included some data from our own experience. Results. Calcineurin antagonists such as tacrolimus and ascomycins (e.g., pimecrolimus) act by inhibiting the activation of the nuclear factor for activated T cells (NFAT). There are new applications for these macrolides that have bee