白癜风胶囊口服配合窄谱中波紫外线照射治疗白癜风疗效观察.docVIP

白癜风胶囊口服配合窄谱中波紫外线照射治疗白癜风疗效观察[摘要]目的：观察白癜风胶囊配合窄谱中波紫外线（NB-UVB）治疗白癜风的疗效。方法：将白癜风患者随机分为3组，治疗组以白癜风胶囊口服配合NB-UVB 照射同时进行；对照1组用白癜风胶囊口服配合8-甲氧补骨脂素溶液外用；对照2组白癜风胶囊口服配合8-甲氧补骨脂素溶液外用同时卡介苗提取素注射液肌注。结果：治疗组疗效明显优于对照1组和对照2组，χ2值分别为11.03和11.49，P＜0.05；对照2组疗效优于对照1组（P＜0.05）。结论：白癜风胶囊口服配合NB-UVB治疗白癜风疗效好。 [关键词]白癜风胶囊；窄谱中波紫外线；照射；白癜风 [中图分类号]R785.4+1 [文献标识码]A [文章编号]1008-6455（2009）02-0232-03 Clinical observation on the therapeutic efficacy ofthe vitiligo oral capsule with narrow-band ultraviolet B radiation（NB-UVB）in treating Vitiligo HUANG Ran，HAO Si-hui (Jiangsu Baoying County Skin Disease Prevents Controls Hospital，Baoying 225800，Jiangsu，China） ObjectiveTo observe the curative effect of Vitiligo treatment with vitiligo oral capsule combined with irradiation of narrow-band ultraviolet B (NB-UVB).MethodsVitiligo patients will be randomly divided into 3 groups as one treatment group and two different control groups. The treatment group will be treated with vitiligo oral capsule combined with NB-UVB irradiation; the control group No.1 with vitiligo oral capsule and 8 - methoxy psoralen topical solution simultaneously; the control group No.2 will be added the intramuscular injection of BCG vaccine extraction on the basis of the treatment of the control group No.1 at the same time. ResultsEfficacy of the treatment group is significantly better than that of control groups No.1 and No.2 with the X2 values are 11.03 and 11.49 (P＜0.05); the control group No.2 is more effective than the control group No.1(P＜0.05).ConclusionThe treatment of vitiligo oral capsule with NB-UVB is good. 白癜风是一种常见多发的色素性皮肤病，表现为局部或泛发性色素脱失,明显影响患者外观美容及社会交往。目前治疗方法很多,疗效不一。笔者应用白癜风胶囊口服配合NB-UVB照射治疗，取得良好效果，现报道如下。 1资料和方法 1.1 临床资料：白癜风患者69例，均来自我院皮肤科门诊，症状典型并且已经排除花斑癣、贫血痣等具有色素减退症状的皮肤病。69例病例中排除活动性肺结核、甲亢、心肝肾功能衰竭、有光感性皮肤病、使用光敏性药物者、12岁以下儿童或年老体弱者、怀孕、皮肤肿瘤、白内障和无晶状体者、接受放疗或同位素治疗者、有黑色瘤病史或家族史、严重光损伤和以前使用离子辐射或砷剂者、免疫功能低下者。所有患者治疗前半个月内均未口服及外用糖皮质激素及其他外用药治疗史。其中肢端型47例，散发型8例，泛发型2例，局限型12例；皮损斑块数个至数十个不等，白斑面积0.8cm×1.7cm～5.5cm×21cm不等。69例分成白癜风胶囊口服配合NB