cross-reaction between the crude hydatid cyst fluid antigens of human and animals origin in response to human igg class and subclasses原油包虫囊肿液之间的交叉反应抗原的人类和动物的起源在回应人类免疫球蛋白类和子类.pdfVIP

Hindawi Publishing Corporation Journal of Parasitology Research Volume 2012, Article ID 947948, 8 pages doi:10.1155/2012/947948 Research Article Cross-Reaction between the Crude Hydatid Cyst Fluid Antigens of Human and Animals Origin in Response to Human IgG Class and Subclasses Afra Khosravi,1, 2 Sobhan Ghafourian,2 Morteza Shamsi,3 Nourkhoda Sadeghifard,2 Abbas Maleki,2 and Ebrahim Babaahmadi3 1 Immunology Department, Faculty of Medicine, Ilam University of Medical Sciences, Ilam 6931994585, Iran 2 Clinical Microbiology Research Center, Ilam University of Medical Sciences Iran, Ilam 6931994585, Iran 3 Parasitology Department, Faculty of Veterinary Sciences, Ilam University, Ilam 6931994585, Iran Correspondence should be addressed to Nourkhoda Sadeghifard, sadeghifard@ Received 7 November 2011; Revised 31 December 2011; Accepted 2 January 2012 Academic Editor: Michael Lanzer Copyright © 2012 Afra Khosravi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The current work aimed to evaluate the cross-reactivity of human immune sera against crude hydatid fluid antigens of sheep, human, mouse, cattle, as well as B fraction of cystic fluid antigen. 30 balb/c mice were infected with sheep hydatid cyct fluid antigen containing protoscolex after the viability of these protoscolices was assessed. ANOVA was used to test the difference of themean of optical density (OD) values among case and control groups. The highest human IgG class antibody was against antigen B (0.93) and the lowest against cattle HCF antigen (0.32). The differences between responses to these antigens were statistically significant (P 0.001). T