原创力文档cyanamide potentiates the ethanol-induced impairment of receptor-mediated endocytosis in a recombinant hepatic cell line expressing alcohol dehydrogenase activity氰氨化强化了ethanol-induced损伤肝细胞系表达重组受体介导的内吞作用的乙醇脱氢酶活性.pdfVIP
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cyanamide potentiates the ethanol-induced impairment of receptor-mediated endocytosis in a recombinant hepatic cell line expressing alcohol dehydrogenase activity氰氨化强化了ethanol-induced损伤肝细胞系表达重组受体介导的内吞作用的乙醇脱氢酶活性
Hindawi Publishing Corporation
International Journal of Hepatology
Volume 2012, Article ID 954157, 5 pages
doi:10.1155/2012/954157
Research Article
Cyanamide Potentiates the Ethanol-Induced Impairment of
Receptor-Mediated Endocytosis in a Recombinant Hepatic Cell
Line Expressing Alcohol Dehydrogenase Activity
Dahn L. Clemens,1, 2 Dean J. Tuma,1, 2 and Carol A. Casey1, 2
1 Liver Study Unit, Department of Veterans’ Aff airs, Omaha, NE 68105, USA
2 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
Correspondence should be addressed to Carol A. Casey, ccasey@
Received 30 July 2011; Accepted 16 November 2011
Academic Editor: Kusum Kharbanda
Copyright © 2012 Dahn L. Clemens et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Ethanol administration has been shown to alter receptor-mediated endocytosis in the liver. We have developed a recombinant
hepatic cell line stably transfected with murine alcohol dehydrogenase cDNA to serve as an in vitro model to investigate these
ethanol-induced impairments. In the present study, transfected cells were maintained in the absence or presence of 25 mM
ethanol for 7 days, and alterations in endocytosis by the asialoglycoprotein receptor were determined. The role of acetaldehyde
in this dysfunction was also examined by inclusion of the aldehyde dehydrogenase inhibitor, cyanamide. Our results showed that
ethanol metabolism impaired internalization of asialoorosomucoid, a ligand for the asialoglycoprotein receptor. The addition of
cyanamide potentiated the ethanol-induced defect in internalization and also
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