decreased cognitivecns function in young adults at risk for hypertension effects of sleep deprivation减少cognitivecns函数在年轻的成年人患高血压睡眠剥夺的影响.pdfVIP

Hindawi Publishing Corporation International Journal of Hypertension Volume 2012, Article ID 989345, 9 pages doi:10.1155/2012/989345 Research Article Decreased Cognitive/CNS Function in Young Adults at Risk for Hypertension: Effects of Sleep Deprivation James A. McCubbin, Hannah Peach, DeWayne D. Moore, and June J. Pilcher Department of Psychology, Clemson University, Clemson, SC 29634, USA Correspondence should be addressed to James A. McCubbin, jmccubb@ Received 27 July 2011; Revised 14 October 2011; Accepted 17 October 2011 Academic Editor: Tavis S. Campbell Copyright © 2012 James A. McCubbin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hypertension has been linked to impaired cognitive/CNS function, and some of these changes may precede development of frank essential hypertension. The stress and fatigue of sleep deprivation may exacerbate these cognitive changes in young adults at risk. We hypothesize that individuals at risk for hypertension will show significant declines in cognitive function during a night of sleep deprivation. Fifty-one young adults were recruited for 28-hour total sleep deprivation studies. Hypertension risk was assessed by mildly elevated resting blood pressure and by family history of hypertension. A series of cognitive memory tasks was given at four test sessions across the sleep deprivation period. Although initially comparable in cognitive performance, persons at risk showed larger declines across the night for several indices of working memory, including code substitution, category, and order recall. These results suggest that cognitive/CNS changes may parallel or pr