原创力文档deposition of charged nano-particles in the human airways including effects from cartilaginous rings沉积的带电纳米粒子在人类航空公司包括来自软骨环的影响.pdfVIP
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deposition of charged nano-particles in the human airways including effects from cartilaginous rings沉积的带电纳米粒子在人类航空公司包括来自软骨环的影响
Vol.3, No.10, 884-888 (2011) Natural Science
/10.4236/ns.2011.310113
Deposition of charged nano-particles in the human
airways including effects from cartilaginous rings
Hans O. Åkerstedt
Department of Applied Physics and Mechanical Engineering, Luleå University of Technology, Luleå, Sweden;
hake@ltu.se
Received 17 August 2011; revised 20 September 2011; accepted 28 September 2011.
ABSTRACT tial health risks of the human lung [1]. In experiments
these particles are known to be electrically charged
This paper presents a numerical study of the
which probably leads to an increase in particle deposition
deposition of spherical charged nano-particles
in the lung. Another important application of charged
caused by convection, Brownian diffusion and
nano-particles is in the design of methods for optimal
electrostatics in a pipe with a cartilaginous ring
drug-aerosol targeting to predetermined lung sites [2].
structure. The model describes the deposition The morphology of the human respiratory airways of
of charged particles in the different generations the human lung is represented by a system of branching
of the tracheobronchial tree of the human lung. tubes where each tube belongs to a certain generation [3].
The upper airways are characterized by a certain
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