development and evaluation of a new interpenetrating network bead of sodium carboxymethyl xanthan and sodium alginate开发和评估一个新的互穿网络珠钠羧甲基黄原胶和海藻酸钠.pdfVIP

Pharmacology Pharmacy, 2010, 1, 9-17 9 10.4236/pp.2010.11002 Published Online July 2010 (http://www.SciRP.org/journal/pp) Development and Evaluation of a New Interpenetrating Network Bead of Sodium Carboxymethyl Xanthan and Sodium Alginate for Ibuprofen Release Rajat Ray, Siddhartha Maity, Sanchita Mandal, Tapan K. Chatterjee, Biswanath Sa The Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. Email: biswanathsa2003@ Received June 6th, 2010; accepted July 8th, 2010. ABSTRACT Interpenetrating network (IPN) beads of sodium carboxymethyl xanthan (SCMX) and sodium alginate (SAL) were pre- pared by ionotropic gelation process using AlCl 3 as a cross-linking agent. The effect of different formulation variables like total polymer concentration, gelation time, concentration of cross-linking agent, and drug load on the extent of release of ibuprofen (IBP), a non steroidal anti-inflammatory drug, was examined. The formation of IPN structure was examined using Fourier Transform Infra-red (FTIR) analysis and the compatibility of the drug in the bead was evalu- ated through FTIR, X-ray diffraction (XRD ) and Differential Scanning Calorimetry (DSC) analyses. While increase in the concentration of total polymer, gelation time, and drug load decreased the drug release in both acidic (pH -1.2) and phosphate buffer (PB) solution (pH -6.8), increase in the concentration of cross-linking agent tended to increase the drug release. However, from all the formulations, the drug release in acidic medium was considerably slow and a maximum 14% of the loaded drug was released in 2 h. Complete drug release was achieved in PB solution within 210 to 330 min depending upon the formulation variables. The release of the drug followed non-Fickian transport process