distinct characteristics in japanese dermatitis herpetiformis a review of all 91 japanese patients over the last 35 years独特的特点在日本疱疹样皮炎回顾所有91名日本患者在过去35年.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 562168, 9 pages doi:10.1155/2012/562168 Research Article Distinct Characteristics in Japanese Dermatitis Herpetiformis: A Review of All 91 Japanese Patients over the Last 35 Years Chika Ohata,1, 2 Norito Ishii,1, 2 Takahiro Hamada,1, 2 Yutaka Shimomura,3 Hironori Niizeki,4 Teruki Dainichi,1, 2 Minao Furumura,1, 2 Daisuke Tsuruta,1, 2 and Takashi Hashimoto1, 2 1 Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan 2 Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan 3 Laboratory of Genetic Skin Diseases, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan 4 Department of Dermatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan Correspondence should be addressed to Takashi Hashimoto, hashimot@med.kurume-u.ac.jp Received 5 January 2012; Revised 22 March 2012; Accepted 29 March 2012 Academic Editor: Marzia Caproni Copyright © 2012 Chika Ohata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We reviewed all 91 Japanese dermatitis herpetiformis (DH) patients reported over the last 35 years. The male-to-female ratio was 2 : 1. The mean age at onset was 43.8, and 13 years earlier for female patients. More than half of these Japanese DH patients showed granular IgA deposition in the papillary dermis, and another one-third showed fibrillar IgA deposition. The male patients with granular I