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HEREDITAS (Beijing) 2009 2 , 31(2): 137―141 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2009.00137 绵羊PRNP 遗传多样性与抗病育种研究进展 1 1 2 2 3 管峰 , 潘磊 , 石国庆 , 刘守仁 , 杨利国 1. , 310018; 2. , 832000; 3. , 430070 朊蛋白(Prion protein, PrP)是近年来被确认的引起人畜共患病的新型病原体, 也是目前证明的具有自我 复制和传播能力的蛋白质。PrP 在多种动物体内表达并具有重要生理作用, 其空间结构改变被认为是可传播性 海绵状脑病(Transmissible spongiform encephalopathies, TSEs) 的根源, 研究发现朊蛋白编码基因(PRNP)遗传多 样性与绵羊对瘙痒病的抗病性具有显著相关性。文章主要介绍了绵羊PRNP 遗传多样性与痒病抗病性的关系以 及PRNP 遗传多样性对繁殖力和其他主要生产性能的影响等方面的研究成果, 旨在为绵羊抗病育种研究提供理 论参考。 绵羊; PRNP ; 遗传多样性; 抗病性; 繁殖力 Research progress on genetic diversity of sheep PRNP and resistance breeding 1 1 2 2 3 GUAN Feng , PAN Lei , SHI Guo-Qing , LIU Shou-Ren , YANG Li-Guo 1. College of Life Sciences, China Jiliang University, Hangzhou 310018, China; 2. The Key Sheep Breeding and Reproduction Biotechnology Laboratory of Xinjiang Production and Construction Group, Shihezi 832000, China; 3. Key Laboratory of Agriculture Animal Heredity, Breeding and Reproduction, Ministry of Education, Huazhong Agriculture University, Wuhan 430070, China Abstract: Prion protein (PrP) is a pathogeny identified in recent years, which infects both mankind and other mammals. It has been proved that PrP is a sole protein able to duplicate and propagate with itself. PrP can express in many tissues and has important physiological functions in many species of animals. The conformation change of PrP is the origin of trans- missible spongiform encephalopathies (TSEs). It has been proved that the shee