屈光参差性弱视面孔刺激大脑皮质激活特征的fMRI研究.docVIP

屈光参差性弱视面孔刺激大脑皮质激活特征的fMRI研究 周 扬1 ,张久权1 ,余琼武2 ,李传明1 ,谢 兵1 ,陈伟1,黄学全1,王 健1* (第三军医大学附属西南医院 1放射科 2 眼科 重庆 400038) 摘　要: 目的 探索屈光参差性弱视面孔及物体认知的大脑皮质功能有无损害及其损害特点。方法 采用组块（BLOCK）设计的BOLD－fMRI研究方法，屈光参差性弱视患者10例及正常对照组11例，分别接受面孔和物体（家具、工具及建筑物）图片的视觉刺激对比，用AFNI软件进行数据处理分析，确定参与面孔及物体认知的脑功能区，选取腹侧颞叶的梭状回作为兴趣区（ROI），计算其激活体积，并对弱视眼戴镜矫正前、后的数据及其与正常对照组和对侧眼分别进行检验，比较其差异，取P ＜ 0.05为有统计学意义。梭状回面孔加工区和物体加工区位置不同。梭状回面孔加工区，弱视眼矫正前后的比较、弱视眼矫正前与正常对照组和对侧眼的比较均有显著差异，但弱视眼矫正后与正常对照组和对侧眼均没有统计学差异，弱视眼与对侧眼在梭状回物体区激活体积的比较则没有显著性差异。 屈光参差性弱视，弱视眼观察时大脑皮质激活范围明显小于对侧眼和正常眼，面孔加工区皮质明显受损，但物体加工区未见明显损害。患眼矫正后可以提高大脑皮质激活的范围和强度，戴镜有益于视力的提高及病情恢复。 fMRI study on face recognition in human anisometropic amblyopia ZHOU Yang1, ZHANG Jiu-quan1, YU Qiong-wu2, LI Chuan-ming1, XIE Bing1, CHEN Wei1, HUANG Xue-quan1, WANG Jian1* (1Department of Radiology, 2Department of Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China) Abstract: Objective To investigate the cerebral areas that response to face recognition and make a preliminary quantitative analysis on their BOLD responses properties. Methods BOLD-fMRI technology and block design were adopted, and the visual stimulations of face and object were presented to 10 amblyopia patients and 11 normal subjects. The data were analyzed with Functional NeuroImages (AFNI) software package to generate brain activation maps. The activation volumes of interests were compared respectively at a P0.05 confidence level. Results Visual cortex, ventri-temporal cortex and the latter parts of parietal lobe were activated in the face and object recognition in all subjects. The accurate positions in the fusiform areas for face and object recognition were different slightly. In amblyopia patients, the extent of face activation areas reduced obviously. Essential activation deficit for the face recognition was in anisometropic amblyopia. Refractive correction significantly increased the amblyopic eye’s cortex activation. Conclusion In amblyopia patients, the cortex activation areas stimulated