a computer model for the simulation of nonspherical particle dynamics in the human respiratory tract一个计算机模型模拟的nonspherical质点动力学在人类呼吸道.pdfVIP

Hindawi Publishing Corporation Physics Research International Volume 2012, Article ID 142756, 11 pages doi:10.1155/2012/142756 Research Article A Computer Model for the Simulation of Nonspherical Particle Dynamics in the Human Respiratory Tract Robert Sturm Brunnleitenweg 41, A-5061 Elsbethen, Salzburg, Austria Correspondence should be addressed to Robert Sturm, sturm rob@ Received 29 April 2011; Accepted 21 October 2011 Academic Editor: Anil Chourasia Copyright © 2012 Robert Sturm. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the study presented here deposition of spheres and nonspherical particles with various aspect ratios (0.01–100) in the human respiratory tract was theoretically modeled. Shape of the nonspherical particles was considered by the application of the latest aerodynamic diameter concepts. Particle deposition was predicted by using a stochastic model of the lung geometry and simulating particle transport trajectories according to the random-walk algorithm. Concerning fibers total deposition is significantly enhanced with respect to that of spheres for μm-sized particles, whereby at normal breathing conditions peripheral lung compartments serve as primary deposition targets. In the case of oblate disks, total deposition becomes mostly remarkable for submicron particles, with the bronchioli and alveoli being targeted to a high extent. Enhancement of the aerodynamic diameter and/or flow rate generally causes a displacement of deposition maxima from peripheral to more proximal lung regions. From these findings, it can be concluded that these particle classes