a diet high in saturated fat and sucrose alters glucoregulation and induces aortic fatty streaks in new zealand white rabbits高饱和脂肪和蔗糖的饮食改变文章和在新西兰白兔诱发主动脉脂质条纹.pdfVIP

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a diet high in saturated fat and sucrose alters glucoregulation and induces aortic fatty streaks in new zealand white rabbits高饱和脂肪和蔗糖的饮食改变文章和在新西兰白兔诱发主动脉脂质条纹.pdf

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a diet high in saturated fat and sucrose alters glucoregulation and induces aortic fatty streaks in new zealand white rabbits高饱和脂肪和蔗糖的饮食改变文章和在新西兰白兔诱发主动脉脂质条纹

Int. Jnl. Experimental Diab. Res. , 3:179–184, 2002 c Copyright 2002 Taylor Francis 1560–4284/02 $12.00 + .00 DOI: 10.1080/15604280290013883 A Diet High in Saturated Fat and Sucrose Alters Glucoregulation and Induces Aortic Fatty Streaks in New Zealand White Rabbits Weidong Yin,12 Zhonghua Yuan,12 Zongbao Wang,1 Baotang Yang,1 and Yongzong Yang1 1Institute of Cardiovascular Research, Nanhua University Medical College, Hengyang, Hunan, People’s Republic of China 2Department of Pathophysiology, Central South University Xiangya Medical College, Changsha, Hunan, People’s Republic of China Type 2 diabetes (non–insulin-dependent diabetes mellitus, A new and convenient animal model for studying peripheral NIDDM) is a major risk factor for atherosclerosis. At equiva- vascular and coronary artery disease in diabetes was established lent conventional risk levels, there is a 4- to 5-fold increase in in this study. Male New Zealand White rabbits weighing approxi- mately 2 kg were divided into 2 groups: a normal control group fed the mortality from vascular disease in diabetic patients, for ex- standard laboratory chow and a diabetogenic diet–fed group re- ample, coronary heart disease caused by atherosclerosis [1, 2]. ceived a high-fat/high-sucrose diet. The high-fat/high-sucrose diet There is also evidence that elevated triglycerides is an impor- (contained 10% lard and 37% sucrose) feeding was maintained for 6 months. Plasma total cholesterol, high-density lipoprotein (HDL) tant cardiovascular risk factor, especially in diabetics [3]. The cholesterol, triglyceride, superoxide dismutase, nitric oxide, nitric mechanism by which diabetes accelerates the development of oxide synthase, insulin, and glucose were quantitated at monthly atherosclerosis needs to