原创力文档a review of the receptor-binding properties of p-synephrine as related to its pharmacological effects回顾p-synephrine的受体结合特性作为其药理作用相关.pdfVIP
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a review of the receptor-binding properties of p-synephrine as related to its pharmacological effects回顾p-synephrine的受体结合特性作为其药理作用相关
Hindawi Publishing Corporation
Oxidative Medicine and Cellular Longevity
Volume 2011, Article ID 482973, 9 pages
doi:10.1155/2011/482973
Review Article
A Review of the Receptor-Binding Properties of p -Synephrine as
Related to Its Pharmacological Effects
Sidney J. Stohs,1 Harry G. Preuss,2 and Mohd Shara3
1 School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA
2 Department of Medicine and Pathology, Georgetown University Medical Center, Washington, DC 22039, USA
3 Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan
Correspondence should be addressed to Sidney J. Stohs, sstohs@
Received 18 January 2011; Accepted 7 June 2011
Academic Editor: Neelam Khaper
Copyright © 2011 Sidney J. Stohs et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p -synephrine are used widely in weight loss/weight
management and sports performance products. Because of structural similarities, the pharmacological effects of p -synephrine are
widely assumed to be similar to those of ephedrine, m-synephrine (phenylephrine), and endogenous amine neurotransmitters
as norepinephrine and epinephrine. However, small structural changes result in the receptor binding characteristics of these
amines that are markedly different, providing a plausible explanation for the paucity of adverse effects associated with the wide-
spread consumption of p -synephrine in the form of dietary supplements as well as in various Citrus foods and juices. This
paper
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