a role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis过氧物酶体的作用proliferator-activated受体在血吸虫病的免疫病理反应.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2012, Article ID 128068, 6 pages doi:10.1155/2012/128068 Review Article A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? Barrie J. Anthony,1 Jeremy T. Allen,2 Yuesheng S. Li,1 and Donald P. McManus1 1 Queensland Institute of Medical Research, Post Offi ce Royal Brisbane Hospital, QLD 4029, Australia 2 Department of Biology, Centre for Parasitology and Disease, Biomedical Sciences Research Institute, University of Salford, Manchester M5 4WT, UK Correspondence should be addressed to Barrie J. Anthony, barrie.anthony@.au Received 1 December 2010; Accepted 27 February 2011 Academic Editor: Marion M. Chan Copyright © 2012 Barrie J. Anthony et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and the accumulation of alternative activated macrophages. This would suggest that at some level, PPARs could have a role in the modulation of the immune response in schistosomiasis. This paper discusses possible areas where PPARs could have a role in this disease. 1. Introduction the DNA [4]. There are 3 isoforms of the PPAR receptors,