abo incompatible liver transplantation as a bridge to treat hellp syndromeabo血型不相容的肝移植治疗临床上妊娠的桥梁.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2009, Article ID 713937, 4 pages doi:10.1155/2009/713937 Case Report ABO Incompatible Liver Transplantation as a Bridge to Treat HELLP Syndrome Kathleen Connor,1 Raymond A. Rubin,2 Roshan Shrestha,1 Mark Johnson,1 Marty Sellers,1 and Brad Butler3 1 Department of Liver Transplantation, Piedmont Hospital, Atlanta, GA 30309, USA 2 Liver Center of Atlanta, Piedmont Hospital, Atlanta, GA 30309, USA 3 Department of Pathology, Piedmont Hospital, Atlanta, GA 30309, USA Correspondence should be addressed to Raymond A. Rubin, raymond.rubin@ Received 21 December 2008; Revised 10 June 2009; Accepted 12 July 2009 Recommended by John Plevris The following is a case report of a primiparous woman who developed fulminant liver failure in the setting of HELLP syndrome complicated by hepatic rupture. It is unique in that a timely ABO compatible liver donor was unavailable, necessitating the transplantation of an ABO incompatible organ. Despite aggressive therapy, severe reperfusion injury and humoral rejection dictated retransplantation with an ABO compatible organ on postoperative day 15, resulting in rapid clinical recovery. Copyright © 2009 Kathleen Connor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. Introduction hemoglobin of 10.1 g/dL, platelet count 106 K/mm3 , aspar- tate aminotransferase (AST) 290 IU/L, and lactate dehydro- Hemolysis, elevated liver enzymes, and low